Abnormal liver function tests in patients with COVID-19

Aim: To evaluate features of changes liver function tests (LFTs) in COVID-19. Methods: We included 50 patients with confirmed COVID-19 and abnormal LFTs. The average age was 55 [46; 66]. 45 (90%) were associated pneumonia. Lung damage involvement according to lungs computed tomography ranged from 5% 70%. Alanine aminotransferase (ALT), aspartate (AST), total bilirubin, gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), quik’s prothrombin protein analyzed. Results: debut cytolysis on 8 [7; 11] sick days ALT levels elevated 2,28 [1,41; 3,27] times. An increase AST correlated (r=0,86; p<0,05), it 2,08 [1,44; 3] De Ritis ratio 0,73 [0,49; 1,15]. Only 2 (4%) had hyperbilirubinemia. 60% an GGT - 1,92 [0,79; 3,05] 1,79 times ALP one patient only. Many not signs hepatocellular insufficiency only 5 (10%) decrease Quik’s prothrombin; hypoproteinemia observed 7 (14%). LFTs reversible, normalization achieved 67%, 76% within a month. (r=0,52; p<0,05) (r=0,48; ferritin. Conclusions: Abnormal characterized by ALT, AST, decreased de ratio. Total ALP, normal most patients. identified the majority cases returned